Top2a cancer

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August undefined, 2024

WebTOP2A Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, TOP2A Genome Browser, TOP2A References TOP2A - Explore an overview of TOP2A, with a … Web1. jan 2024 · TOP2A is an enzyme that controls the topological states of DNA. It catalyzes double-strand DNA breaking and promotes gene transcription during mitosis [3]. It has …

TOP2A gene copy number change in breast cancer - PubMed

Web1. apr 2014 · This study investigated the potential ways and consequences of etoposide resistance in MCF-7 breast cancer cells. Etoposide-resistant sublines of MCF-7 developed in our laboratory have been investigated earlier for expression of TOP2A encoding the topoisomerase II isoform and two mismatch repair genes, MLH1 and MSH2. Here, a more … Web1. máj 2024 · In addition, TOP2A could be considered as valuable prognostic biomarkers to identify prostatic patients, non-small cell lung cancer and lung cancer (Hou et al., 2024; Labbe et al., 2024; Ma et al., 2024). A study proved that autoantibody against TOP2A could identify lung cancer patients, benign lung disease from normal control (Pei et al., 2024). mairie de thoury ferrottes

DNA topoisomerase 1 and 2A function as oncogenes in liver cancer …

Web21. aug 2024 · The aim of the present study was to determine the role of topoisomerase 1 (TOP1) and topoisomerase 2A (TOP2A) in liver cancer (LC), and to investigate the inhibitory effect of nitidine chloride (NC) on these two topoisomerases. Immunohistochemistry (IHC) staining and microarray or RNA sequencing data mining showed markedly higher … Webtop2a PATHOLOGY LIVER CANCER BREAST CANCER CARCINOID CERVICAL CANCER COLORECTAL CANCER ENDOMETRIAL CANCER GLIOMA HEAD AND NECK CANCER … WebTOP2A (TOP2) protein expression summary. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcripti on. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and … mairie facebook lombez

Alteraciones del gen TOP2A - Histopat laboratoris

Targeting DNA topoisomerase II in cancer chemotherapy - Nature

Web15. jan 2024 · Many studies have shown that TOP2A can be a prognostic biomarker and potential therapeutic target for bladder cancer, such as bladder urothelial carcinoma (BLCA), lung adenocarcinoma, prostate cancer, colon cancer and breast cancer [ 12, 13, 14, 15, 16 ]. WebBAZ2A-RNA dependent association with TOP2A and KDM1A represses gene expression in prostate cancer: Organism: Homo sapiens: ... Summary: In this study we show that in prostate cancer, the RNA-binding TAM domain of BAZ2A is required for the repression of Pol II genes that are frequently silenced in the metastatic disease. In contrast to rRNA gene ... mairie gohoryWebAnthracycline is a DNA topoisomerase 2-α (TOP2A) inhibitor and its concomitant over expression with Human Epidermal Growth Factor Receptor 2 (HER2) was investigated of … mairie etrechy facebook

"Web12. sep 2003 · To determine the frequency of genomic alterations of HER-2 and TOP2A in bladder cancer, we analyzed the subset of 1,853 tumor samples representing the first … " - Top2a cancer

Top2a cancer

TOP2A as marker of response to pegylated lyposomal doxorubicin …

Web2. nov 2024 · TOP2A is essential for cell division, is highly expressed during mitosis, and is required for mitotic chromosome condensation and segregation ( 13 – 16 ). Genetic … WebTOP2A. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.

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Web13. feb 2024 · Relapsed epithelial ovarian cancer (EOC) is frequently treated with pegylated liposomal doxorubicin (PLD). Unfortunately, most patients do not benefit from treatment. Prediction of response is crucial to optimize PLD use and avoid unnecessary toxicities. We aimed at assessing the value of topoisomerase II alpha (TOP2A) expression as predictive … Web31. mar 2024 · Further studies showed that CDK1 that interacts with TOP2A was significantly reduced after TOP2A knockdown. We demonstrated that CX258 significantly inhibited DLD-1 CRC cell xenografts in SCID mice. In summary, we identified CX258 as a promising candidate for colorectal cancer treatment by targeting the TOP2A/Wnt/β …

Web7. aug 2014 · HER2 and TOP2A genes are coamplified in breast and some other cancers. In this study, we investigated gene aberrations of HER2 and TOP2A and protein expressions … WebThis section contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The …

Web10. dec 2024 · TOP2A plays a vital role in both cancer-inhibiting and cancer-promoting processes . The tissue type and the tumor microenvironment have different effects on the process of carcinogenesis due to the different roles of TOP2A. In our study, there was a majority of HCMV-positive tumor tissues expressing high levels of TOP2A mRNA … Web28. feb 2024 · In breast cancer, TOP2A expression is closely related to the occurrence and development of tumors and its efficacy on chemotherapy drugs (21,22). It has been noted that the higher the histological grade of breast-invasive ductal carcinoma, the worse the differentiation of tumor cells, and the higher the expression of the TOP2A gene .

Web11. sep 2024 · Using bioinformatic analysis, we revealed that TOP2A could be adopted as a prognostic indicator of NSCLC and it potentially regulate cancer development through co …

WebTOP2A deletion (gene to chromosome ratio ≤0.8) or monosomy (only one signal for both gene and chromosome in more than 75% of nuclei) were classified as gene loss. Results: … mairie de wittisheimWebPred 1 dňom · Anthracycline plus taxane regimens are most efficacious at reducing breast cancer recurrence and death. Regimens with higher cumulative doses of anthracycline plus taxane provide the greatest benefits, challenging the current trend in clinical practice and guidelines towards non-anthracycline chemotherapy, particularly shorter regimens, such … mairie guilly 45WebTOP2, TP2A Topoisomerase (DNA) II alpha (TOP2A) is a gene that encodes a protein that controls and alters topologic states of DNA during transcription. Missense mutations, … mairie garche thionvilleWeb8. sep 2014 · Our results indicated that TOP2A was the most highly upregulated gene in recurrent/metastatic prostate cancer, and its high expression was positively correlated with poor prognosis in patients. Using a promoter reporter system, we unexpectedly discovered enrichment of CSCs in TOP2Anegcells. mairie fresnoy en thelleWebPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. TOP2A is not prognostic in cervical cancer. Alive (n=220) mairie freyming merlebach adresseWeb27. mar 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect … mairie genthod cffWeb21. mar 2024 · TOP2A (DNA Topoisomerase II Alpha) is a Protein Coding gene. Diseases associated with TOP2A include Malignant Peripheral Nerve Sheath Tumor and … mairie corniche sete