WebJul 23, 2024 · bioRxiv.org - the preprint server for Biology WebSep 9, 2024 · IFITM3 also has potential as a diagnostic marker for late-onset AD, with high levels of expression possibly a strong risk factor. Perhaps most exciting is the potential mechanistic link between AD and neuroinflammation, the underappreciated third pathological feature of AD after amyloid plaques and tau tangles. Inflammatory states …
Protein Palmitoylation in Leukocyte Signaling and Function
WebJan 14, 2024 · Interferon (IFN)-induced transmembrane proteins (IFITM1, IFITM2 and IFITM3) have emerged as important gatekeepers of pathogen infection in vertebrates 1. Initial siRNA knockdown studies of IFITM3 ... WebSep 8, 2024 · IFITM3 restricts HCMV-induced TLR2-mediated cytokine production by human DCs Next, we sought to investigate whether IFITM3 regulated virus-induced cytokine … engineering finance jobs
mTOR inhibitors lower an intrinsic barrier to virus infection ... - PNAS
WebJul 28, 2024 · In dendritic cells, IFITM3 binds to the reticulon 4 isoform Nogo-B and promotes its proteasomal degradation. We reveal that Nogo-B mediates TLR-dependent pro-inflammatory cytokine production and promotes viral pathogenesis in vivo, and in the case of TLR2 responses, this process involves alteration of TLR2 cellular localization. ... WebMycobacterium tuberculosis (MTb) and TLR2/4 signaling induce IFITM1–3 transcription ... We find that IFITM3 co-localizes with early and, in particular, late MTb phagosomes, and overexpression of IFITM3 enhances endosomal acidification in MTb-infected monocytic cells. These findings provide evidence that the antiviral IFITMs participate in the ... WebJul 28, 2024 · The three best-characterized members of the IFITM family are IFITM1, IFITM2, and IFITM3 8,9,10,11. They contain different sorting motifs and IFITM1 is mainly localized at the plasma membrane, ... engineering final exam