Webb1 jan. 2002 · The optimal two-stage design was proposed by Simon. This method determines the adequate sample size by calculating the response probability of two groups with α and β errors [1, 2].... WebbThis program generates Simon's optimal two-stage designs (Simon, 1989) and admissible designs from Jung et al. (2004) for Phase II single arm clinical trials. 1. Simon R (1989). …

Simon

WebbIn 1989, Simon ( 9) optimized Fleming’s 2-stage design as follows. He suggested that early stopping not be allowed for dramatically positive results, in the interest of achieving more precise estimates of the response rate by accruing to the full sample size in these cases. Webbtwo-stage design that is optimal in the sense that the expected sample size is minimized if the regimen has low activity subject to constraints upon the size of the type 1 and type 2 errors. Two-stage designs which minimize the maximum sample size are also determined. simon2stage(p0, pa, alpha, beta, eps =0, N_min, N_max, int =0, d3dx dll not found

Simon 2-stage function — simon2stage • PhIIdesign

Webb2 Two-stage designs with and without curtailment rules 2.1 Minimax and optimal designs The objective of Simon’s two-stage design is to test whether a new treatment should be … Webb28 juli 2024 · Since Rich Simon proposed optimal design and minimax design for two-stage phase II trials in 1986, either of them has been chosen for most of phase II clinical trials. When designing a phase II trial, however, clinical trialists almost always question which design to select. WebbThis paper presents two-stage designs that are optimal in the sense that the expected sample size is minimized if the regimen has low activity subject to constraints upon the … bingo ndr livestream