Web9 aug. 2024 · MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and … WebSMYD2 is a lysine histone methyl transferase involved in various cancers epigenetically via methylating histone H3K4, and H3K36. c-Myc is one of the major drivers of prostate …
The atypical ubiquitin ligase RNF31 stabilizes c-Myc via ... - PubMed
WebThe Myc-dependent survival signal generated by E2 was dependent upon basal levels of mTOR (mammalian target of rapamycin) and two upstream regulators of mTOR, phosphatidylinositol 3-kinase and phospholipase D (PLD). Stable elevated expression of PLD2 also increased Myc expression and provided a Myc-dependent survival signal in … Web9 aug. 2024 · MYC usually forms as a heterodimer with MAX (MYC/MAX) to bind to DNA in E-box region (CACGTG). This structure mainly contains the basic-region (BR), helix-loop-helix (HLH), and leucine-zipper (LZ), which are required for DNA binding Full size image Fig. 2 Schematics of MYC protein and its transcriptional activity. traduci soak
Cell-to-cell variability in Myc dynamics drives transcriptional ...
WebMYCN Is an Oncogenic Driver in Many Types of Cancers. Deregulation of MYCN occurs in both pediatric cancers and adult cancers. MYCN amplification has been found in … Web13 jun. 2003 · To understand the molecular targets of c-Myc function, we have used an unbiased genome-wide location-analysis approach to examine the genomic binding sites … Web21 mrt. 2024 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit.Among its related pathways are Prolactin Signaling and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.Gene Ontology (GO) … traduci snorkeling