WebSep 27, 2024 · Mechanical overloading is a major cause of tendinopathy, but the underlying pathogenesis of tendinopathy is unclear. Here we report that high mobility group box1 (HMGB1) is released to the tendon extracellular matrix and initiates an inflammatory cascade in response to mechanical overloading in a mouse model. WebJun 14, 2024 · In January 2024, we reported an important role for FBXW7 in the association between mechanical overloading, chondrocyte senescence and cartilage ageing in the pathology of osteoarthritis (OA).1 Our data support the idea that JNK signalling pathway is activated in OA, and DTP3 can inhibit JNK in chondrocytes.1 Two of our observations …
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WebMechanistically, mechanical overloading decreased Fbxw7 mRNA transcription and FBXW7-mediated MKK7 degradation, which consequently stimulated JNK signalling. In particular, inhibition of JNK activity by DTP3, a MKK7 inhibitor, ameliorated chondrocyte senescence and cartilage degenerationConclusionsFBXW7 is a key factor in ... WebJun 14, 2024 · Shao Y, Yao Z. Mechanical overloading promotes chondrocyte senescence 1 Zhang H, and osteoarthritis development through downregulating FBXW7. Ann Rheum Dis 2024;81:676–86. 2 Loeser RF, Kelley KL, Armstrong A, et al. Deletion of JNK enhances senescence in joint tissues and increases the severity of age-related osteoarthritis in … how to hack koobits
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WebJun 25, 2015 · Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration. Masato Koike 1,2, … WebApr 4, 2024 · Mechanical overloading could promote chondrocyte senescence and senescence-associated secretory phenotype (SASP) expression. MicroRNA-array … WebSep 27, 2024 · Mechanical overloading is a major cause of tendinopathy, but the underlying pathogenesis of tendinopathy is unclear. Here we report that high mobility group box1 (HMGB1) is released to the tendon extracellular matrix and initiates an inflammatory cascade in response to mechanical overloading in a mouse model. how to hack lclc