Irf4 t cell
WebJan 20, 2024 · The transcription factor interferon regulatory factor 4 (IRF4) is critical for development of the immune system, especially B and T cells. The IRF4 International Consortium identified seven patients from six families with a combined immunodeficiency who harbored a recurrent heterozygous mutation in IRF4, p.T95R. WebSep 1, 2024 · Concept: Cooperation between BATF and IRF4 enhanced tumor inhibition and promoted memory T-cell formation. Impact: Countering T-cell exhaustion via induced …
Irf4 t cell
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WebDec 7, 2024 · Roquin deficiency or IRF4 overexpression potently enhances anti-tumor immunity. These data provide a functional catalog of CD8 T cell fitness genes and suggest that targeting the Roquin-IRF4 axis is an effective strategy to enhance efficacy of adoptive transfer therapy for cancer. Graphical abstract View Large Image Download Hi-res image WebDec 6, 2024 · In agreement with the lack of a role for STAT3 in TNF-Th17 cell generation, TNF-induced IRF4 up-regulation was similar in STAT3-deficient and WT CD4 + T cells (SI Appendix, Fig. S6D). The dependence of TNF-Th17 generation on IRF4 was shown by the reduction of ROR-γt expression ( Fig. 2 J ) and IL-17A production ( Fig. 2 K ) in its absence.
WebApr 11, 2024 · CD8 + T cells are crucial for the clearance of viral infections. During the acute phase, proinflammatory conditions increase the amount of circulating phosphatidylserine + (PS) extracellular vesicles (EVs). These EVs interact especially with CD8 + T cells; however, it remains unclear whether they can actively modulate CD8 + T cell responses. In this … WebAug 1, 2024 · BATF-transduced CAR T cells exhibit enhanced tumor rejection. A preliminary screen for TFs that could enhance NFAT:AP-1 activity in CD8 + T cells led us to JUN, MAFF, and BATF (Extended Data Fig. 1), and raised the question whether JUN, MAFF, or BATF could confer a functional anti-tumor advantage on CD8 + CAR T cells in vivo.. CD8 + T cells …
WebAug 26, 2013 · Robust cytotoxic CD8 + T-cell response is important for immunity to intracellular pathogens. Here, we show that the transcription factor IFN Regulatory Factor 4 (IRF4) is crucial for the protective CD8 + T-cell response to the intracellular bacterium Listeria monocytogenes.IRF4-deficient (Irf4 −/−) mice could not clear L. monocytogenes … WebSep 1, 2024 · Further analysis revealed cooperation between BATF and another transcription factor, interferon regulatory factor 4 (IRF4), to be vital for the exhaustion resistance phenotype, and CAR T cells expressing a BATF variant with lower affinity for IRF4 did not delay tumor growth or survive in tumors in mice.
WebDec 23, 2024 · CD8+T cell exhaustion is a state of T cell dysfunction during chronic infection and tumor progression. Exhausted CD8+T cells are characterized by low effector function, high expression of inhibitory receptors, unique metabolic patterns, and altered transcriptional profiles. Recently, advances in understanding and interfering with the …
IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40. IRF4 can function either as an activating or an inhibitory transcription factor depending on its transcription chubby ray\\u0027s louisvilleWebFeb 1, 2014 · In the immune system, IRF4 is critical for development and maturation of multiple lineages of blood cells. In T cells development, IRF4 is essential for the differentiation of Th1, Th2, Th9, Th17 and T reg subsets. In B lymphocytes, IRF4 promotes light chain rearrangement and transcription and is critical for B cell development at the … designer cut off shortsWebIRF4 Is Highly Induced in Graft-Infiltrating T Cells and Is Required for Heart Transplant Rejection IRF4 is a key transcription factor for translating TCR signaling into proper T cell … designer cutlery sets indiaWebMar 29, 2024 · IRF4 on the other hand regulates cDC2 subsets, which express high levels of CD11b and CD172 in both mouse and humans and are highly efficient at inducing CD4 + T cell effector function and expansion. High expression of IRF8 in combination with E2-2 and Bcl11A are required for development of pDCs, which secrete high amounts of type I IFN in ... chubby reader insWebJun 3, 2024 · Although the precise regulatory mechanisms at play for IRF4 in T cells have yet to be fully elucidated, levels of IRF4 have been shown to be higher in resting Th2 cells compared to Th1 and Th17 . Inquiries into the role of IRF5 in other immune cell types have revealed alternative roles for IRF4 outside that of direct transcriptional regulation. chubby reader fanficsWebMar 29, 2024 · In terms of T cell-related markers, the results showed that the expression levels of the transcriptional regulator TBX-21 (T-bet) and interferon regulatory factor 4 (IRF4) were significantly upregulated in peripheral blood of the patients in the EPL group (P < 0.05), whereas the expression levels of GATA binding protein 3 (GATA3) and ... chubby rays jtownWebWe found that IRF4 was promptly induced in T cells upon TCR signaling through the MEK1/2 pathway. IRF4 ablation in T cells resulted in progressive establishment of CD4 + T cell dysfunction and induced heart allograft acceptance in mice. The dysfunctional state of Irf4 −/− T cells was initially reversible by blocking programmed death-ligand 1 (PD-L1) and … chubby ray\\u0027s jeffersontown ky