Irf3 transcription factor
WebSep 19, 2013 · IRF3 is a constitutively expressed transcription factor that resides in the cytoplasm and dimerizes and translocates to the nucleus upon phosphorylation ().Phosphorylated IRF3 induces IFN-β during viral infection, but may also contribute to inflammatory cytokine response to LPS ().IRF3 also promotes apoptosis in virus-infected … WebTranscription factors IRF3 activates toll-like receptor-independent type I IFN production, which are very important in inducing IFN-γ production. 32 IFN-α/β is one of the most …
Irf3 transcription factor
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WebUsing cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. Mechanistically, IRF3 binds the NF-κB–p65 subunit and prevents its … Web1 day ago · STING recruitment of TBK1 and IRF3 results in IRF3 phosphorylation by TBK1 and IRF3 55 nuclear translocation[18, 19]. Activated STING also activates IKK and the NF-κB family of 56 transcription factors[20], which with IRF3, activate expression of type I IFN and subsequently 57 ISGs. ISGs include an array of anti-HIV restriction factors ...
WebIRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. Following virus infection, IRF-3 is posttranslationally modified by protein phosphorylation at multiple serine and threonine residues, located in the carboxy-terminus of IRF-3. WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other …
WebJan 8, 2024 · Transcriptional activation of the IFNβ promoter by IRF3/7 has been extensively studied (9, 10), and proceeds with phosphorylation of IRF3/7 by the kinase TKB1, leading … WebThe transcription factor IFN regulatory factor 3 (IRF3) plays an essential role in this process (3, 4). It was also reported that IRF3 is required to protect the host from viral infections, …
WebMar 29, 2024 · IRF3 is activated by phosphorylation (by kinases TBK1 and IKKε), promoting dimerization, nuclear translocation, association with the co-activator CREB-binding protein …
WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … openpyxl save and close fileWebOct 15, 2024 · Using two model transcription factors, IRF3 and STAT1, we demonstrate that transcription factor dimerization enables the trans-autoacetylation of p300 in a highly … openpyxl scatterchart 線種WebNov 1, 2012 · IRF3 and IRF7 have multiple sites that—upon viral infection—are substrates for phosphorylation by the serine/threonine kinases TANK-binding kinase 1 (TBK1) and IκB … openpyxl set row styleWebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation of the transcription factor interferon regulatory factor 3 (IRF3) and consequent induction of host immune responses to RNA viruses. openpyxl save to bytesioWebUsing cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. … openpyxl save as xlsxWebIRF3 is a transcription factor which is a major regulator of the type I interferon (IFN) antiviral response after recognition of viral DNA or RNA by intracellular foreign nucleic acid sensors, such as Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and cyclic GMP-AMP synthase (cGAS) (reviewed in [10]). IRF3 activa- openpyxl read rowWebMar 9, 2024 · IRF3 is a major transcriptional regulator of adipose inflammation and is involved in maintaining systemic glucose and energy homeostasis Findings indicate that STING-TBK1-IRF3 pathway mediates a crosstalk between ER stress and apoptosis during M. bovis infection, which can effectively control intracellular bacteria. ipad repairs torquay