WebThiazides and related diuretics may also cause hypokalaemia and metabolic alkalosis via a similar mechanism to loop diuretics. Thiazides and related diuretics are commonly used for the treatment of hypertension. This is not due to their direct diuretic effect, but because they cause vasodilation (the mechanism for this is poorly understood). WebAug 27, 2024 · Thiazide diuretic (TZD)-mediated chronic reduction of arterial pressure is thought to occur through decreased total peripheral vascular resistance. Further, the decreased peripheral vascular resistance is accomplished through TZD activation of an extrarenal target, resulting in inhibition of vascular constriction.
Diuretics - Mayo Clinic
WebAug 13, 2024 · Diuretics, sometimes called water pills, help rid your body of salt (sodium) and water. Most of these medicines help your kidneys release more sodium into your urine. The sodium helps remove water from your blood, decreasing the amount of fluid flowing through your veins and arteries. This reduces blood pressure. WebDirect vasodilators directly affect the muscle cells that line your blood vessels. They make your muscle cells relax so that blood vessels open. Because they work quickly, they can … boy meets world older brother
Drug-Induced Glucose Alterations Part 2: Drug-Induced …
WebFeb 12, 2016 · Thiazides---->inhibit NaCl in DCT------>increased Na excretion------>ECF contraction---->decrease GFR------------>ultimately increase in Na and water resorption in PCT---->decrease urine output. I hope I did that right. Don't know if this answers your Q tho. Dang-it obiwan, you beat me to the punch... 0 M medstu2006 Senior Member 10+ Year Member WebMay 15, 2024 · Research shows that thiazide-type diuretics (chlorthalidone and indapamide) are superior in preventing cardiovascular disease at a lower cost. Recommendations are to start them as first-line treatment for hypertension. WebSep 7, 2024 · Thiazide and thiazide-like diuretics have been a mainstay of the therapy of primary hypertension. The most popular agent in this class, hydrochlorothiazide, was traditionally used in doses of 50 to 100 mg/day. These doses were associated with metabolic and electrolyte complications. Low-dose therapy has since been demonstrated … gw2 experience after 80