Ddb1 and cul4 associated factor 6

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August undefined, 2024

WebMar 21, 2024 · This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009] GeneCards Summary for DCAF12 Gene WebApr 5, 2024 · DTL是CUL4-DDB1相关因子（DDB1 and CUL4 associated factor，DCAF）之一，可能参与恶性肿瘤的发展过程[2]。Cullin-RING E3泛素连接酶（Cullin-RING E3 ligase，CRL）拥有庞大的家族，参与基因转录、细胞周期调控、细胞分化、增殖、凋亡和肿瘤发生等过程[3]。DTL作为连接酶中的底物 ...

UniProt

WebThe cullin 4 (CUL4)-damage-specific DNA binding protein 1 (DDB1)-cereblon (CRBN) E3 ubiquitin ligase co-exists in the same complex with and promotes the degradation of ClC … WebDDB1 is also a component of an ubiquitin-E3 ligase complex and functions as substrate or adapter protein between Cullin 4A (Cul4A) and CUL4-associated factors (DCAFs) to target substrates for ubiquitination. CUL4-DDB1 E3-ligase complex regulates the selective proteolysis of key proteins in DNA repair, replication and transcription. new movies september

DDB1- and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is …

WebMar 30, 2024 · We also identified cellular DCAF receptors in CRL4 complexes from humanized mice. Increasing amounts of HBx did not reveal competitive DCAF binding to cullin4 (CUL4)-DDB1 in plasmid-transfected cells. Our results suggest a model in which HBx benefits virus replication by directly or indirectly degrading multiple cellular restriction … WebMembers of the DDB1-CUL4-associated factors (DCAFs) family directly bind to DAMAGED DNA BINDING PROTEIN1 (DDB1) and function as … WebMore than 20 partner proteins of DDB1, collectively called DDB1- and CUL4-associated factors (DCAFs) [162,163], have been identified; these include CSA (Cockayne syndrome group A protein, involved in transcription-coupled NER) and Cdt2 (Cdc10-dependent transcript 2, which regulates DNA replication and DNA damage responses) in addition to … introducing themselves

DCAF15 - Wikipedia

WebDCAF16 DDB1 and CUL4 associated factor 16 [ (human)] Gene ID: 54876, updated on 6-Sep-2024 Summary Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2024] Other designations DDB1- and CUL4-associated factor 16 GeneRIFs: Gene References Into … WebMar 21, 2024 · DCAF10 (DDB1 And CUL4 Associated Factor 10) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation . UniProtKB/Swiss-Prot Summary for DCAF10 Gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase … new movies scary moviesWebApr 14, 2024 · DDB1- and CUL4-associated factor 8 (DCAF8) is a WD40 repeat-containing protein, which serves as a substrate receptor for CRL4. The physiological role of DCAF8 is unknown. In this study, we constructed Dcaf8 knockout mice. Homozygous mice were viable with no noticeable abnormalities. new movies scary 2022

"WebSep 28, 2024 · DCAF6 DDB1 and CUL4 associated factor 6 [ (human)] Gene ID: 55827, updated on 28-Sep-2024. Summary. The protein encoded by this gene is a ligand … " - Ddb1 and cul4 associated factor 6

Ddb1 and cul4 associated factor 6

WebDCAF15. DDB1 and CUL4 associated factor 15 is a protein that in humans is encoded by the DCAF15 gene. [5] DCAF15 forms a complex with CUL4A or CUL4B that has E3 ubiquitin ligase activity and is responsible for the proteasome degradation of … Web(redirected from DDB1 and CUL4 associated factor 6) DCAF6 A gene on chromosome 1q24.2 that encodes a ligand-dependent coactivator that enhances the …

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WebJun 22, 2007 · The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the substrate receptors that dictate the specificity of this ubiquitination machinery have been largely unknown. Recent work identified a family of D DB1 and C UL4- a ssociated f … WebDDB1- and CUL4-associated factor 8 (DCAF8) is a WD40 repeat-containing protein, which serves as a substrate receptor for CRL4. The physiological role of DCAF8 is unknown. In this study, we constructed Dcaf8 knockout mice.

WebThe Cul4-DDB1[VprBP] E3 ubiquitin ligase complex is identified as the downstream effector of lentiviral Vpr for the induction of cell cycle arrest in G2 phase. Recruitment of cytoplasmic protein Vpr binding protein (VprBP) by HIV-1 regulatory protein Vpr is essential for its cytostatic activity. WebMar 21, 2024 · DDB1- and CUL4-associated factor 16 Protein Accession: Q9NXF7 Secondary Accessions: B3KPB7 Protein attributes for DCAF16 Gene Size: 216 amino acids Molecular mass: 24193 Da Protein existence level: PE1 Quaternary structure: Interacts with DDB1 and CUL4A. Three dimensional structure from AlphaFold (predicted) for DCAF16 …

WebDCAF12 (CT102, DKFZP434O125, KIAA1892, MGC1058, TCC52, WDR40A) protein expression summary. WebJun 7, 2004 · DDB1- and CUL4-associated factor 7. Alternative names. WD repeat-containing protein 68; WD repeat-containing protein An11 homolog; Gene names. Name. DCAF7. Synonyms. HAN11, WDR68. Organism names. Organism. Homo sapiens (Human) Taxonomic identifier. 9606 NCBI. Taxonomic lineage.

WebNX_Q58WW2 - DCAF6 - DDB1- and CUL4-associated factor 6 - Function. Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

WebRecommended articles (6) Developmental Biology. Volume 490, October 2024, Pages 66-72. DDB1- and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for … new movies september 2015WebMouse Gene Ddb1 (ENSMUST00000025649.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default) Description: Mus musculus damage specific DNA binding protein 1 (Ddb1), mRNA. (from RefSeq NM_015735) ... Full=UV-damaged DNA-binding factor; new movies screamWebThe cullin 4 (CUL4)-damage-specific DNA binding protein 1 (DDB1)-cereblon (CRBN) E3 ubiquitin ligase co-exists in the same complex with and promotes the degradation of ClC-2 channels. The CRBN-targeting immunomodulatory drug lenalidomide and the cullin E3 ligase inhibitor MLN4924 promotes and attenuates, respectively, proteasomal … introducing the new bing翻译WebOct 4, 2024 · Among E3 ubiquitin ligases known to be involved in the ubiquitination of Nrf2, DDB1 and Cullin4 associated factor 11 (DCAF11) was down-regulated at both protein and mRNA levels in stable cells, indicating that the repression of DCAF11 by TFEB may be mainly involved in the stabilization of Nrf2. ... DDB1 and CUL4 associated factor 11, … new movies scriptWebMouse Gene Ddb1 (ENSMUST00000025649.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default) Description: Mus musculus damage … new movies sept 2022WebNov 27, 2015 · Little is known on post-transcriptional regulation of adult and embryonic stem cell maintenance and differentiation. Here we characterize the role of Ddb1, a … introducing the nervous systemWebJun 7, 2004 · DDB1- and CUL4-associated factor 7. Alternative names. WD repeat-containing protein 68; WD repeat-containing protein An11 homolog; Gene names. Name. … introducing the new azure sdks