WebNov 30, 2024 · The increased uptake detected in the M2 population might explain the cisplatin hypersensitivity of this cell type described in the literature. (63−65) However, … Webglomerular filtration rate, higher serum creatinine, and reduced serum magnesium and potassium levels.4,19,20 On the other hand, the long-term effects of cisplatin on renal ... the cisplatin uptake is due to passive diffusion through the plasma membrane, and the remaining half is mediated by an unknown transporter.22 In 2002, ...
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WebMay 1, 2008 · CISPLATIN UPTAKE AND METABOLISM. The mechanism of intracellular transport of cisplatin is not clear and may vary from one cell type to another. Earlier work using cancer cell lines concluded that about half of the cisplatin uptake is due to passive diffusion through the plasma membrane, and the remaining half is mediated by an … WebJan 11, 2024 · Studies in cells also showed that cisplatin can be taken up by passive diffusion mechanisms since its accumulation by concentration gradient up to its saturation point was not the rate limiting factor ( … in and out burger dallas texas
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WebThe uptake of cisplatin in renal tubular cells is high, leading to cisplatin accumulation and tubular cell injury and death, culminating in acute renal … The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity Am J Physiol Renal Physiol. WebApr 17, 2024 · Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss. As cisplatin is … WebBoth solvated and non-solvated simulations show that cisplatin release rates can be controlled by either ... energies and small pore window diameters will hinder cisplatin … in and out burger dallas locations