site stats

Cisplatin uptake rates

WebNov 30, 2024 · The increased uptake detected in the M2 population might explain the cisplatin hypersensitivity of this cell type described in the literature. (63−65) However, … Webglomerular filtration rate, higher serum creatinine, and reduced serum magnesium and potassium levels.4,19,20 On the other hand, the long-term effects of cisplatin on renal ... the cisplatin uptake is due to passive diffusion through the plasma membrane, and the remaining half is mediated by an unknown transporter.22 In 2002, ...

Drug uptake-based chemoresistance in breast cancer treatment

WebMay 1, 2008 · CISPLATIN UPTAKE AND METABOLISM. The mechanism of intracellular transport of cisplatin is not clear and may vary from one cell type to another. Earlier work using cancer cell lines concluded that about half of the cisplatin uptake is due to passive diffusion through the plasma membrane, and the remaining half is mediated by an … WebJan 11, 2024 · Studies in cells also showed that cisplatin can be taken up by passive diffusion mechanisms since its accumulation by concentration gradient up to its saturation point was not the rate limiting factor ( … in and out burger dallas texas https://cgreentree.com

Optimal cisplatin cycles in locally advanced cervical carcinoma ...

WebThe uptake of cisplatin in renal tubular cells is high, leading to cisplatin accumulation and tubular cell injury and death, culminating in acute renal … The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity Am J Physiol Renal Physiol. WebApr 17, 2024 · Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss. As cisplatin is … WebBoth solvated and non-solvated simulations show that cisplatin release rates can be controlled by either ... energies and small pore window diameters will hinder cisplatin … in and out burger dallas locations

Calculating the dose of cisplatin that is actually utilized in ...

Category:Differential effects of cisplatin in proximal and distal renal tubule ...

Tags:Cisplatin uptake rates

Cisplatin uptake rates

Mechanisms of cell uptake and toxicity of the anticancer …

WebJul 1, 2024 · 1. Introduction. Breast cancer is the most common cancer in women and the second leading cause of death due to cancer among women globally. New statistics published in 2024 suggest that 30% of women will develop breast cancer in their lifetime and 15% of them will die from it [1].Even though breast cancer incidence has increased …

Cisplatin uptake rates

Did you know?

WebOct 3, 2014 · One possible mechanism by which resistance is reported to develop is a reduction in drug uptake across the cell membrane. While the passive uptake of cisplatin has long been cited as an... WebOct 7, 2002 · We have also found that cisplatin reduced uptake of 64 Cu into wild-type cells; when treated for 2 h with 1 mM cisplatin, the level of 64 Cu uptake was 16% of that of …

WebCisplatin (cDDP) is an anti-cancer drug used to treat a number of malignancies including breast, testicular, ovarian, prostrate, lung, head, neck, and colon cancers. Recent studies have... WebFeb 28, 2024 · Cisplatin is a highly polar species, and its cellular accumulation generally occurs at a slower rate compared with that of other small-molecule anticancer drugs. Apart from passive diffusion, other non-saturable systems, such as fluid-phase endocytosis, may be involved in platinum drug uptake, and evidence for some active or facilitated ...

WebDec 30, 2024 · To maintain resistance in A2780cisR cells, cisplatin (1 μ M) was added to the medium every two passages. Continuous treatments (CT) were carried out at 37°C in a humidified chamber with 5% CO 2. Cisplatin was dissolved in a 0.9% w/v NaCl aqueous solution and brought to pH = 3 with HCl (final stock concentration 1 mM). WebJan 11, 2024 · In this regard, evidence suggests that the major mechanisms involved in cisplatin uptake are through passive diffusion and through facilitated transporters in particular organic cation transporters, such as, copper transporters (Ctr1) (Ishida et al., 2002). Transmembrane passive diffusion is a process that depends on both the size and ...

WebCisplatin Prices, Coupons and Patient Assistance Programs. Cisplatin is a member of the alkylating agents drug class and is commonly used for Anal Cancer, Bladder Cancer, …

WebDec 18, 1998 · Cisplatin transport characteristics demonstrated a saturable component of cisplatin uptake and differences in apparent K M and V max values among the three … in and out burger dallas grand openingWebOct 5, 2014 · The addition of cisplatin to cyclophosphamide and doxorubicin (CAP) has been recently associated with overall response rates of 57% to 100% and complete … inbetweeners first day backWebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … in and out burger dallas txWebSep 18, 2024 · NCBI Bookshelf in and out burger dcWebNational Center for Biotechnology Information in and out burger dallas hoursWebNov 7, 2024 · One of the main limitations to the Pt-therapy in cancer is the development of associated drug resistance that can be associated with a significant reduction of the … inbetweeners fashion show simonWebWhen infused from the basolateral compartment, cisplatin (25 µM, 72 hours) induced toxicity, which was evident as reduced cell number and reduced barrier integrity compared with vehicle-treated chip cultures. Coexposure with the OCT2 inhibitor cimetidine (1 mM) abolished cisplatin toxicity. in and out burger davis ca