WebWe hypothesized that Euonymus sachalinensis (ES) induces apoptosis by inhibiting the expression of c-Myc in colon cancer cells, and this study proved that the methanol extract of ES has anticancer effects in colon cancer cells. ES belongs to the Celastraceae family and is well known for its medicinal properties. Extracts of species belonging to this family … WebWestern blot analysis of extracts from control HEK293 cells (lane 1) or c-Myc knockout HEK293 cells (lane 2) using c-Myc (D84C12) Rabbit mAb Antibody, #5605 (upper) or β-actin (13E5) Rabbit mAb, #4970 (lower). The absence of signal in the c-Myc knockout HEK293 cells confirms specificity of the antibody for c-Myc. Show Less Show More
Regulation of cancer cell metabolism: oncogenic MYC in …
WebApr 5, 2024 · In this review, we discuss the role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c-MYC dysregulation, and their effect on prognosis and diagnosis in specific types of B-cell lymphoma. Webc-Myc has been implicated in multiple cellular processes, including proliferation, differentiation, apoptosis and metabolism 2. The four-helix structure of c-Myc and MAX binds to DNA sequences, such as E-box motifs (5’-CACGTG -3’), to control transcription of specific genes. These genes have been reported to be involved in chromatin ... toy soldier song four seasons
The many roles of c-Myc in apoptosis - PubMed
WebAug 7, 2024 · MYC Deregulation in Cancer. The MYC transcription factor family consists of c-, L-, and N-MYC. The aberrant expression or activity of any one of these family members has been shown to contribute to tumor development, although the latter two seem to be restricted to specific tissues, most prominently lung and neural, respectively [8–11].MYC … WebMar 30, 2024 · (E) N-terminal FAM21-myc or C-terminal FAM21-myc fragments were transduced into wild-type, SWIP KO, or VPS35 KO cell lines. Resulting stable cell lines were fixed and labeled with antibodies targeting myc tag (green) and EEA1 (magenta). (F) Quantification of co-localization between FAM21-myc fragments and EEA1 in stable cell … WebApr 26, 2024 · This review outlines the nature and regulation of the c- myc gene and of c-Myc and presents the systems and conditions in which Myc-related apoptotic events occur. Hypotheses of the mechanisms by which expression and repression of c- myc lead to apoptosis are discussed. Keywords apoptosis; c- myc; cell death; induction; repression. toy soldier song youtube