WebMay 8, 2009 · Subsequently, Atg4 protease cleaves the tail sequence to generate form-I LC3, which has a C-terminal glycine. ... An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in ... WebMay 7, 2024 · neurodegeneration. The Atg4-Atg8 system is an important piece of the molecular machinery of macroautophagy/autophagy in yeast. Atg4 protease catalyzes the initial activating cleavage of Atg8, which is required for the binding of this protein to a molecule of phosphatidylethanolamine at the phagophore. Once at the phagophore …
An Atg4B mutant hampers the lipidation of LC3 paralogues and …
WebApr 25, 2008 · ATG4 1 Systematic Name YNL223W SGD ID SGD:S000005167 Aliases AUT2 27 ... Non-essential gene; null mutant is unable to undergo autophagy and late nucleophagy, displays reduced mitophagy, and has defects in both micronucleophagy and the CVT pathway; null mutant displays decreased viability during nitrogen starvation and … WebOct 10, 2024 · We confirmed these data in vitro, where this mutant Atg4 variant bound to recombinant (non-lipidated) Atg8 as wild type Atg4. We thus identified a distinct region in yeast Atg4, which does not act like a classical LIR motif but rather is particularly important for the association of Atg4 with lipidated Atg8 (Atg8-PE) and hence named it APEAR ... county of mendocino board meeting
Cancers Free Full-Text Targeting ATG4 in Cancer Therapy
WebAutophagy-related gene 4 (ATG4) is essential for autophagy by affecting autophagosome formation through processing full-length microtubule-associated protein 1A/1B-light chain 3 (pro-LC3) and lipidated LC3. ... Fukumoto, H.; Omori, H.; Yamamoto, A.; Noda, T.; Yoshimori, T. An Atg4B mutant hampers the lipidation of LC3 paralogues and causes ... WebIn the process of autophagy, a ubiquitin-like molecule, LC3/Atg8, is conjugated to phosphatidylethanolamine (PE) and associates with forming autophagosomes. In … WebAug 31, 2012 · UAS-Atg4[C98A] transgenics were established as described below. ... Omori H, Yamamoto A, et al. (2008) An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Molecular Biology of the Cell 19: 4651–4659. View Article Google Scholar 14. ... county of merced